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KMID : 0364219750180030131
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Korean Journal of Zoology
1975 Volume.18 No. 3 p.131 ~ p.140
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Sensitization Effects of Thymidine Analogs on Methyl Methanesulfonate Induced DNA Repair synthesis
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Park Sang-Dai
Um Kyung-Il
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Abstract
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Dose response for the nuscheduled DNA synthesis induced by various concentration of MMS was dose dependent and directly proportional to dose increased. Time dependence of unscheduled DNA synthesis was continued up to 4 hours, with the peak appearing 2$\\sim$3 hours after treatment with MMS and $^3 H$-thymidine labeling. Single treatment with BUdR or IUdR does not induce unscheduled DNA synthesis. BUdR and IUdR greatly enhanced MMS-induced unscheduled DNA synthesis, but the dose responses were different from that of single treatment with MMS. IUdR was found to be more effective sensitizer on MMS-induced unscheduled DNA synthesis.
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KEYWORD
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